A to Z of MS Nystagmus

Nystagmus is a potential symptom of multiple sclerosis causing involuntary eyes movements. The movements can be from side to side, up and down, or in a rotary manner. This sometimes goes unnoticed by the person with MS but is clearly seen by an observer. If it is more persistent, nystagmus may contribute to dizziness or nausea.

Nystagmus can be a difficult symptom to treat. Occasionally drug therapy can help. The NICE Guideline for management of MS states that "any person who has nystagmus that causes reduced visual acuity or other visual symptoms should be offered a time-limited trial of treatment with oral gabapentin. This should be initiated and monitored by a suitable specialist".

A small study suggests that memantine is also effective.

Reference

Prasad S, Galetta SL.
Eye movement abnormalities in multiple sclerosis.
Neurologic Clinics 2010 ;28(3):641-655.
abstract

Shery T, et al.
The effects of gabapentin and memantine in acquired and congenital nystagmus: a retrospective study.
British Journal of Ophthalmology 2006;90(7):839-843.
abstract

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